Department of Dermatology

Brand Lab

My laboratory focuses the role of oxidative-stress on epithelial barrier dysfunction.  Specifically, we study the synergism between alcohol abuse and other stressors, such as radiation, on the generation of epithelial trauma, effectiveness of wound healing and severity of inflammatory skin diseases such as psoriasis. Additionally, we take advantage of the observation that the immunosuppressive effects of EtOH are greater in tissues with high EtOH levels to study the use of ID vaccination in place of IM in individuals with significant alcohol consumption.  Furthermore, we employ topically applied novel, antioxidants as therapeutic agents capable of preventing or mitigating radiation-induced skin damage.