Department of Dermatology

Jonathan J. Lee, MD

  • 3rd Year Resident: PGY-IV

Jonathan J. Lee, MD began his residency at the University of Pittsburgh in July, 2016.

Dr. Lee received his undergraduate degree, in public health, from the University of California, Berkeley. He went on to earn his medical degree from Harvard Medical School.  Dr. Lee completed additional training in the form of a post-junior fellowship in pathology, at Brigham and Women's Hospital, and completed his internship at Mount Auburn Hospital before beginning his residency program in Pittsburgh.

Dr. Lee is currently a reviewer for the Journal of Cutaneous Pathology and is the Chairman of the Medical Advisory Board, Global Brigades, 501(c)3.

Education & Training

  • B.A., University of California, Berkeley
  • M.D., Harvard Medical School
  • Internship, Mount Auburn Hospital, Harvard Medical School

Representative Publications

  • Lee JJ, Lian CG. Molecular Testing for Cutaneous Melanoma: An Update and Review. Arch Pathol Lab Med. 2018: In Press.

  • Lee JJ, English JC 3rd. Ulcerative necrobiosis lipoidica responsive to JAK inhibition for polycythemia vera. JAMA Dermatol. 2018. Jun 1;154(6):733-734. 

  • Lee JJ, English JC 3rd. Teledermatology: A Review and Update. Am J Clin Dermatol. 2018. Apr;19(2):253-260. 

  • Tucker DW, Getchell CR McCarthy ET, Ohman AW, Sasamoto N, Xu S, Ko JY, Gupta M, Shafrir A, Medina JE, Lee JJ, et al. Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer. Clin Cancer Res. 2017 Dec 20. doi: 10.1158/1078-0432.CCR-17-1958. [Epub ahead of print]

  • Lee JJ, Dando E, Bibee K, Jedrych J, Ho J, Patton T. Early-onset basal cell carcinoma in young female endurance athletes: A report of three cases. Skin. 2016 Sep;1(2):105-106.

  • Lee JJ, Kroshinsky D, Hoang MP. Adverse cutaneous drug eruptions to targeted therapy. Am J Dermatopathol. 2017: Feb;39(2):67-82.

  • Lee JJ, Vilain RE, Granter SR, Hu N, Bresler S, Xu S, Frank AH, Mihm, Jr MC, Fletcher CD, Scolyer RA, Murphy GF, Lian CG. 5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms. J Cutan Pathol. 2016 Dec 29. [Epub ahead of print]

  • Lee JJ, Jedrych J, Pantanowitz L, Ho J. Validation of digital pathology for primary histopathological diagnosis of routine, inflammatory dermatopathology cases. Am J Dermatopathol. 2017. In Press.

  • Lee JJ, Lian CG. Loss of 5-hydroxymethycytosine: Enhancing precision in the diagnosis and prognosis of cutaneous malignant melanoma. Pub Health Emerg. 2017. In Press.

  • Lee JJ, Mihm MC, Cook M, Murphy GF, Lian CG, et al. Loss of the Epigenetic Mark, 5-hydroxymethylcytosine, Correlates with Small Cell/Nevoid Subpopulations and Assists in Microstaging of Human Melanoma. Oncotarget. 2015 Nov 10;6(35):37995-8004.

  • Lee JJ, Lindeman NI, Chin G, Hodi FS, Ott PA, Luke JJ, Granter SR, Laga AC, Yoon CH, Haynes HA, Werchniak AE, Lin JY, Liu R, Bailey N, Murphy GF, Lian CG. Targeted next generation sequencing of treatment-naïve metastatic melanoma specimens reveals high frequency of epigenetic alterations. Clinical Epigenetics. 2015 June 9;7(1):59.

  • Lee JJ, Granter SR, Laga AC, Saavedra A, Zhan Q, Guo W, Xu S, Murphy GF, Lian CG. 5-hydroxymethylcytosine distinguishes between metastatic melanoma and nodal nevi in sentinel lymph node biopsies. Modern Pathology. 2015 Feb;28(2):218-29.

  • Lee JJ, Murphy GF, Lian CG. Melanoma epigenetics: New mechanisms, markers, and medicines. Laboratory Investigation. 2014: 2014 Aug;94(8):822-38.

  • Lee JJ, Mochel MC, Piris A, Boussahmain C, Mahalingam M, Hoang MP. p40 exhibits superior specificity than p63 in distinguishing between primary cutaneous adnexal carcinomas and cutaneous metastasis. Human Pathology. 2014 May;45(5):1078-83.

  • Lee JJ, Kim GE, Luo L, Girouard SD, Carlberg VC, Mostaghimi A. Palliative Management of Refractory Pruritus Associated with Carcinoma Eryspieloides et en Cuirasse. BMJ Palliative & Supportive Care. 2016 Mar;6(1):119-21.Lee JJ Frankel HC, Mostaghimi A, Murphy GF, Lian CG. Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy. Dermatopathology. 2014;1:75-80.

  • Lee JJ, Nambudiri VE, Henneberry J, Larson AR, Wanner M. Post-Transplant Diagnosis of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) Syndrome in a Kidney Donor. Clinical Kidney Journal. 2014. 7 (6): 615-616.

  •  Lee JJ, Frankel HC, Mostaghimi A, Murphy GF, Lian CG. Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy. Dermatopathology. 2014;1:75-80.

  • Guo W, Xu T, Lee JJ, Murphy GF, Lian CG. Epigenetic Markers in Melanoma. Melanoma Manag. 2015 Nov;2(4):367-82.

  • Wang T, Xu C, Zhou X, Li C, Zhang H, Lian BQ, Lee JJ, Shen J, Liu Y, Lian CG. Homozygous ALOXE3 nonsense variant identified in a patient with non-bullous congenital ichthyosiform erythroderma complicated by superimposed bullous majocchi’s granuloma: The consequences of skin barrier dysfunction. Int J Molec Sci. 2015 Sep 9;16(9):21791-801. 

  • Tao W, Xu C, Zhou X, Li C, Zhang X, Lee JJ, Liu Y, Lian CG. Novel ERCC5 Mutations Identified in a Chinese Family of a Xeroderma Pigmentosum Complement Group G Patient. Journal of the American Academy of Dermatology Case Reports. 2015 Mar;1(2):66-70.

  • Milner DA, Lee JJ, Frantzreb C, et al. Quantitative Assessment of Whole Body Tissue Sequestration in Fatal Pediatric Cerebral Malaria. J Infect Dis. 2015 Oct 15;212(8):1317-21.

  • Lee JJ, Bredella MA, Springfield DS, Nielsen . Soft tissue angiofibroma: A case report. Skeletal Radiology. 2014 Mar;43(3):403-7.

Textbook Chapters

  •      Lee JJ, Hoang MP (2014). Cutaneous lymphoid infiltrates in patients receiving biologic modifiers. In Cualing HD, Kadin ME, Hoang MP, Morgan MB (Ed.) Cutaneous Hematopathology: Approach to the Diagnosis of Atypical Lymphoid-Hematopoietic Infiltrates in Skin. New York, NY: Springer.
  •      Lee JJ, Kroshinsky D, Hoang MP (2015). Acute generalized exanthematous pustulosis. In Hall JC, Hall BJ (Ed.) Cutaneous Drug Eruptions. New York, NY: Springer.

Research Interests

Epigenetic biomarkers in dermatopathology, digital pathology, recreational/athletic sun exposure and skin cancer risk/prevention.